The Week 4 college football schedule is when recent conference realignment makes its presence felt as seven schools will play their first conference games in a new league this week. This includes No. 11 USC, which is a 5.5-point favorite in the latest Week 4 college football odds, as the Trojans make their Big Ten debut against No. 18 Michigan. Additionally, No. 15 Oklahoma will contest its first SEC game as it takes on No. 6 Tennessee (-7). The other ranked matchup on Saturday has No. 12 Utah favored by 1.5 points, per the Week 4 college football lines, as the Utes will make their Big 12 debut against No. 14 Oklahoma State.

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